Bergamaschi, Daniele

Daniele Bergamaschi

Daniele Bergamaschi

BSc, PhD
Non clinical Senior Lecturer

Recent and ongoing research projects In my lab we have two lines of research currently going on:

Molecular signalling pathways involved in the epidermal homeostasis. Therefore we are interested in proliferation, adhesion, differentiation, motility, apoptosis and autophagy within the stratified epithelia, by using keratinocytes cell lines, organotypic skin reconstructs and normal epidermis as a model. Our aim is to identify the key molecular signalling pathways that fine tune the homeostatic process in the epidermal epithelia and eventually monitor how they could be deregulated in the specific types of cutaneous malignancies.

In melanoma we are particular interested in the intrinsic resistance of melanocytes to apoptosis during malignant progression. Our research goal is to understand the physiological roles of the key players involved in apoptosis in melanocytes and melanoma cells, with a special regards to the p53 family members signalling pathways somehow altered in melanomas. At this regard we are also exploring the role of cancer stem cells in melanoma.

Bio

 

After my BSc in Biological Science at the University of Milan in 1994, I studied Cancer Pharmacology at a postgraduate level at the Mario Negri Institute of Pharmacological Research in Milan until 1998. I then moved to London where I worked as a postdoctoral research fellow at the Ludwig Institute for Cancer Research at the UCL with Professor Xin Lu. In November 2005 I was appointed as a Lecturer at the Centre for Cutaneous Research, in the Blizard Institute and in 2009 I was promoted to Senior lecturer.

 

Research

Apoptosis resistance in melanoma
Molecular signalling pathways involved in the epidermal homeostasis

Melanoma, skin cancer, apoptosis, autophagy, cell cycle, differentiation, gene expression, microRNA.

Publications

Key Publications

Chikh A, Matin RNH, Senatore V, Hufbauer M, Lavery D, Raimondi C, Ostano P, Mello-Grand M, Ghimenti C, Bahta A, Khalaf S, Akgül B, Braun K, Chiorino G, Philpott MP, Harwood CA and Bergamaschi D. iASPP/p63 auto-regulatory feedback loop is required for the homeostasis of stratified epithelia". The EMBO Journal (2011) doi:10.1038/emboj.2011.302.

Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N, Smith P, Gasco M, Crook T, Lu X. iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet. 2006 Oct; 38(10):1133-1141.

Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X. ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol. 2004 Feb; 24(3):1341-50.

Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M, Numico G, Comino A, Attard M, Reelfs O, Gusterson B, Bell AK, Heath V, Tavassoli M, Farrell PJ, Smith P, Lu X, Crook T. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell. 2003 Apr; 3(4):387-402.

Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE , Lu X. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet. 2003 Feb; 33(2):162-7.

Samuels-Lev Y*, O'Connor DJ*,

Bergamaschi D*, Trigiante G, Hsieh JK, Zhong S, Campargue I, Naumovski L, Crook T, Lu X. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell. 2001 Oct; 8(4):781-94. ( *equal contribution).


All publications from PubLists

For additional publications please click here
 

Teaching

SSM in dermatology, BMed Science Cutaneous Module,
PBL tutors, SSC2 tutor

Mentor of Y1 and Y2 medical students

PhD Students:

Rubeta NH Matin
Folake Akinduro
Manuela Graf

Contact

Blizard Institute
Barts and The London School of Medicine and Dentistry
Blizard Building
4 Newark Street
London
E1 2AT

+44 (0) 20 7882 2567
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