BSc (University of Newcastle), PhD (University of Manchester), DSc (University of Manchester). Post-doctoral fellow with Professor Alan Bennett (Kings College Hospital Medical School). Fellow of the British Pharmacology Society. Drug Discovery and Gastrointestinal Research at GlaxoSmithKline. Experience in all phases of drug discovery, placing 7 novel compounds into development, including granisetron (now an anti-emetic drug).
Research achievements have include the proposal that a novel receptor mediated the ability of 5-HT to increase gastrointestinal motility, later named by others as the 5-HT4 receptor. Identification of the role of the 5-HT3 receptor in the mechanisms of emesis, which led to the development of new drugs and a major change in the treatment of cancer. Jointly awarded the 1998 Discoverer’s Award by the Pharmaceutical Research and Manufacturers of America (PhRMA). Exploration actions mediated by NK3, ghrelin and motilin receptors. Consultant on gastrointestinal drug discovery and development.
Research profile: functional human tissue assays
Using fresh, ethically-obtained human gastrointestinal tissues to predict activity in vivo. Functional human tissue assays include those which study neuromuscular pharmacology, human mucosal permeability and mucosal secretion and in the near future, human peristalsis. Assays are complimented by human gastrointestinal immunohistochemistry, to confirm the cell types of interest. In the functional human tissue assays, actions of novel substances are benchmarked against those of clinically-relevant drugs, enabling us to predict physiological, therapeutic and adverse effects of novel substances in the clinic, and the potency and doses of new drugs. Our focus on human tissue pharmacology means we are involved in basic research with immediate clinical relevance, as well as providing contract services to industry, playing a vital role in innovative drug discovery.