David van Heel

Title: Professor
BM BCh MA DPhil FRCP
Professor of Gastrointestinal Genetics

Research Theme: Genomic Medicine

I did a Natural Sciences BA at Cambridge University in 1990 and completed Clinical Medicine training at University of Oxford in 1993. A Medical Research Council Clinical Training Fellowship led to a DPhil from the Wellcome Trust Centre for Human Genetics, University of Oxford in 2002. I was then a Wellcome Trust Clinician Scientist Fellow at Imperial College London from 2002 to 2006. I completed specialist medical training as a Consultant in Gastroenterology in 2004.

In 2006, I was appointed to Professor of Gastrointestinal Genetics at Barts and The London School of Medicine and Dentistry, and Honorary Consultant Gastroenterologist at Barts and the London NHS Trust. 
 
My main clinical and research focus is coeliac disease and Crohn's disease, with a more general interest in the ‘autoimmune’ diseases.
 
I was awarded the 2009 Sir Francis Avery Jones Research Award by the British Society of Gastroenterology.

Research

My main research interests are the genetic causes of coeliac disease, Crohn's disease and type 1 diabetes, and the functional/immunological consequences of these genetic variants on human biology.

Achievements include:

  • Demonstrating that Crohn's disease associated NOD2 variants are loss of function in human cells (2005).
  • Performing the first genome wide association study in coeliac disease, identifying variants in the IL2-IL21 region (2007).
  • Identifying a further seven coeliac disease associated gene regions (2008). Interestingly many regions are shared with other autoimmune diseases (e.g. type 1 diabetes, 2008), mostly with the same SNP allele but in some cases a different SNP or with the alternate SNP allele.
  • Establishing high-throughput sequencing at the Barts and The London Genome Centre (2008/9).
  • Developing a new method to understand the function of disease associated genetic variants: high throughput Illumina GAII sequencing for allele specific expression (2009). As proof of principle, we show that multiple sclerosis risk variants in CD6 alter the level of CD6 expression.

I have current or recent funding and/or support from:

  • Juvenile Diabetes Research Foundation
  • Medical Research Council
  • Wellcome Trust
  • Coeliac UK.

Recent and ongoing research projects:

  • Genetic risk factors for coeliac disease
  • Shared and distinct genetic risk factors across the different chronic immune diseases
  • Understanding how chronic immune disease genetic risk factors alter (human) immuno-biology
  • Towards new diagnostics and therapeutics for chronic immune diseases, based on advances in understanding the genetic basis of disease

Publications

Key Publications

Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC,  Bhaw-Rosun L, Bockett NA, Brand OJ, Brouwer E, Concannon P, Cooper JD, Dias KR, van Diemen CC, Dubois PC, Edkins S, Fölster-Holst R, Fransen K, Glass DN, Heap GA, Hofmann S, Huizinga TW, Hunt S, Langford C, Lee J, Mansfield J, Marrosu MG, Mathew CG, Mein CA, Müller-Quernheim J, Nutland S, Onengut-Gumuscu S, Ouwehand W, Pearce K, Prescott NJ, Posthumus MD, Potter S, Rosati G, Sambrook J, Satsangi J,  Schreiber S, Shtir C, Simmonds MJ, Sudman M, Thompson SD, Toes R, Trynka G, Vyse  TJ, Walker NM, Weidinger S, Zhernakova A, Zoledziewska M; Type 1 Diabetes Genetics Consortium; UK Inflammatory Bowel Disease (IBD) Genetics Consortium; Wellcome Trust Case Control Consortium, Weersma RK, Gough SC, Sawcer S, Wijmenga  C, Parkes M, Cucca F, Franke A, Deloukas P, Rich SS, Todd JA, van Heel DA. Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet. 2012;44(1):3-5. doi: 10.1038/ng.1037. PubMed PMID: 22200769; PubMed Central PMCID: PMC3287292.

Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, Bhaw-Rosun L, Castillejo G, de la Concha EG, de Almeida RC, Dias KR, van Diemen CC, Dubois PC, Duerr RH, Edkins S, Franke L, Fransen K, Gutierrez J, Heap GA, Hrdlickova B, Hunt S, Izurieta LP, Izzo V, Joosten LA, Langford C, Mazzilli MC, Mein CA, Midah V, Mitrovic M, Mora B, Morelli M, Nutland S, Núñez C, Onengut-Gumuscu S, Pearce K, Platteel M, Polanco I, Potter S, Ribes-Koninckx C, Ricaño-Ponce I, Rich SS, Rybak A, Santiago JL, Senapati S, Sood A, Szajewska H, Troncone R, Varadé J, Wallace C, Wolters VM, Zhernakova A; Spanish Consortium on  the Genetics of Coeliac Disease (CEGEC); PreventCD Study Group; Wellcome Trust Case Control Consortium (WTCCC), Thelma BK, Cukrowska B, Urcelay E, Bilbao JR, Mearin ML, Barisani D, Barrett JC, Plagnol V, Deloukas P, Wijmenga C, van Heel DA. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet. 2011 Nov 6;43(12):1193-201. doi: 10.1038/ng.998. PubMed PMID: 22057235; PubMed Central PMCID: PMC3242065.

Blaydon DC, Biancheri P, Di WL, Plagnol V, Cabral RM, Brooke MA, van Heel DA,  Ruschendorf F, Toynbee M, Walne A, O'Toole EA, Martin JE, Lindley K, Vulliamy T,  Abrams DJ, MacDonald TT, Harper JI, Kelsell DP. Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med. 2011 Oct 20;365(16):1502-8. PubMed PMID: 22010916.

Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A,  Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin  ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V,  Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA. Multiple common variants for celiac disease influencing immune gene expression. Nat Genet. 2010 Apr;42(4):295-302. Epub 2010 Feb 28. PubMed PMID: 20190752; PubMed Central PMCID: PMC2847618.

Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med. 2008 Dec 25;359(26):2767-77. Epub 2008 Dec 10. PubMed PMID: 19073967; PubMed Central PMCID: PMC2840835.

Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA. Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet. 2008 Apr;40(4):395-402. Epub 2008 Mar 2. PubMed PMID: 18311140; PubMed Central PMCID: PMC2673512.

van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar  MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P,  Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C. A genome-wide association study for celiac disease identifies risk variants in the  region harboring IL2 and IL21. Nat Genet. 2007 Jul;39(7):827-9. Epub 2007 Jun 10. PubMed PMID: 17558408; PubMed Central PMCID: PMC2274985.

van Heel DA, Ghosh S, Butler M, Hunt KA, Lundberg AM, Ahmad T, McGovern DP, Onnie C, Negoro K, Goldthorpe S, Foxwell BM, Mathew CG, Forbes A, Jewell DP, Playford RJ. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet. 2005 May 21-27;365(9473):1794-6. PubMed  PMID: 15910952.

All publications from PubLists

Hunt KA, Smyth DJ, Balschun T et al. (2012). Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.. Nat Genet Vol.44, (1) 3-5.
10.1038/ng.1037
Fu J, Wolfs MG, Deelen P et al. (2012). Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.. PLoS Genet Vol.8, (1) e1002431-.
10.1371/journal.pgen.1002431
Trynka G, Hunt KA, Bockett NA et al. (2011). Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.. Nat Genet Vol.43, (12) 1193-1201.
10.1038/ng.998
Nanty L, Carbajosa G, Heap GA et al. (2011). Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates.. Genome Res Vol.21, (11) 1841-1850.
10.1101/gr.121640.111
Blaydon DC, Biancheri P, Di WL et al. (2011). Inflammatory skin and bowel disease linked to ADAM17 deletion.. N Engl J Med Vol.365, (16) 1502-1508.
10.1056/NEJMoa1100721
Blaydon DC, Nitoiu D, Eckl KM et al. (2011). Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion.. Am J Hum Genet Vol.89, (4) 564-571.
10.1016/j.ajhg.2011.09.001
Westra HJ, Jansen RC, Fehrmann RS et al. (2011). MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects.. Bioinformatics Vol.27, (15) 2104-2111.
10.1093/bioinformatics/btr323
Cotsapas C, Voight BF, Rossin E et al. (2011). Pervasive sharing of genetic effects in autoimmune disease.. PLoS Genet Vol.7, (8) e1002254-.
10.1371/journal.pgen.1002254
Fehrmann RS, Jansen RC, Veldink JH et al. (2011). Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.. PLoS Genet Vol.7, (8) e1002197-.
10.1371/journal.pgen.1002197
Billmann-Born S, Till A, Arlt A et al. (2011). Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.. J Immunol Vol.186, (7) 4027-4038.
10.4049/jimmunol.1000085
Festen EA, Goyette P, Green T et al. (2011). A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.. PLoS Genet Vol.7, (1) e1001283-.
10.1371/journal.pgen.1001283
Trynka G, Wijmenga C, van Heel DA (2010). A genetic perspective on coeliac disease.. Trends Mol Med Vol.16, (11) 537-550.
10.1016/j.molmed.2010.09.003
Tye-Din JA, Stewart JA, Dromey JA et al. (2010). Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.. Sci Transl Med Vol.2, (41) 41ra51-.
10.1126/scitranslmed.3001012
Zhernakova A, Elbers CC, Ferwerda B et al. (2010). Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection.. Am J Hum Genet Vol.86, (6) 970-977.
10.1016/j.ajhg.2010.05.004
Dubois PC, Trynka G, Franke L et al. (2010). Multiple common variants for celiac disease influencing immune gene expression.. Nat Genet Vol.42, (4) 295-302.
10.1038/ng.543
Heap GA, Yang JH, Downes K et al. (2010). Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.. Hum Mol Genet Vol.19, (1) 122-134.
10.1093/hmg/ddp473
Heap GA, van Heel DA (2009). Genetics and pathogenesis of coeliac disease.. Semin Immunol Vol.21, (6) 346-354.
10.1016/j.smim.2009.04.001
Soranzo N, Spector TD, Mangino M et al. (2009). A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.. Nat Genet Vol.41, (11) 1182-1190.
10.1038/ng.467
Coenen MJ, Trynka G, Heskamp S et al. (2009). Common and different genetic background for rheumatoid arthritis and coeliac disease.. Hum Mol Genet Vol.18, (21) 4195-4203.
10.1093/hmg/ddp365
Garner CP, Murray JA, Ding YC et al. (2009). Replication of celiac disease UK genome-wide association study results in a US population.. Hum Mol Genet Vol.18, (21) 4219-4225.
10.1093/hmg/ddp364
Romanos J, van Diemen CC, Nolte IM et al. (2009). Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease.. Gastroenterology Vol.137, (3) 834-840.e3.
10.1053/j.gastro.2009.05.040
Trynka G, Zhernakova A, Romanos J et al. (2009). Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.. Gut Vol.58, (8) 1078-1083.
10.1136/gut.2008.169052
Heap GA, van Heel DA (2009). The genetics of chronic inflammatory diseases.. Hum Mol Genet Vol.18, (R1) R101-R106.
10.1093/hmg/ddp001
Hunt KA, van Heel DA (2009). Recent advances in coeliac disease genetics.. Gut Vol.58, (4) 473-476.
10.1136/gut.2008.155879
Koskinen LL, Einarsdottir E, Dukes E et al. (2009). Association study of the IL18RAP locus in three European populations with coeliac disease.. Hum Mol Genet Vol.18, (6) 1148-1155.
10.1093/hmg/ddn438
Dubois P, Hunt K, van Heel D (2009). Sex differences in HLA DQ in celiac disease.. Am J Gastroenterol Vol.104, (3) 784-.
10.1038/ajg.2009.16
Heap GA, Trynka G, Jansen RC et al. (2009). Complex nature of SNP genotype effects on gene expression in primary human leucocytes.. BMC Med Genomics Vol.2, () 1-.
10.1186/1755-8794-2-1
Smyth DJ, Plagnol V, Walker NM et al. (2008). Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease. NEW ENGL J MED Vol.359, (26) 0028-4793 2767-2777.
Dubois PC, van Heel DA (2008). Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.. Clin Exp Immunol Vol.153, (2) 162-173.
10.1111/j.1365-2249.2008.03704.x
Adamovic S, Amundsen SS, Lie BA et al. (2008). Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.. Genes Immun Vol.9, (4) 364-367.
10.1038/gene.2008.27
Franke L, de Kovel CG, Aulchenko YS et al. (2008). Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays.. Am J Hum Genet Vol.82, (6) 1316-1333.
10.1016/j.ajhg.2008.05.008
Dubois PC, van Heel DA (2008). New susceptibility genes for ulcerative colitis. NAT GENET Vol.40, (6) 1061-4036 686-688.
10.1038/ng0608-686
Zhernakova A, Festen EM, Franke L et al. (2008). Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.. Am J Hum Genet Vol.82, (5) 1202-1210.
10.1016/j.ajhg.2008.03.016
Hunt KA, Franke L, Deloukas P et al. (2008). No evidence in a large UK collection for celiac disease risk variants reported by a Spanish study. GASTROENTEROLOGY Vol.134, (5) 0016-5085 1629-1630.
10.1053/j.gastro.2008.03.068
Wapenaar MC, Monsuur AJ, van Bodegraven AA et al. (2008). Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis.. Gut Vol.57, (4) 463-467.
10.1136/gut.2007.133132
Hunt KA, Zhernakova A, Turner G et al. (2008). Newly identified genetic risk variants for celiac disease related to the immune response.. Nat Genet Vol.40, (4) 395-402.
10.1038/ng.102
Monsuur AJ, de Bakker PI, Zhernakova A et al. (2008). Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.. PLoS One Vol.3, (5) e2270-.
10.1371/journal.pone.0002270
Butler M, Chaudhary R, van Heel DA et al. (2007). NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's disease. J CROHNS COLITIS Vol.1, (2) 1873-9946 106-115.
10.1016/j.crohns.2007.08.006
Zhernakova A, Alizadeh BZ, Bevova M et al. (2007). Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.. Am J Hum Genet Vol.81, (6) 1284-1288.
10.1086/522037
Marchbank T, Mahmood A, Fitzgerald AJ et al. (2007). Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents.. Am J Pathol Vol.171, (5) 0002-9440 1462-1473.
10.2353/ajpath.2007.070192
van Heel DA, Franke L, Hunt KA et al. (2007). A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.. Nat Genet Vol.39, (7) 1061-4036 827-829.
10.1038/ng2058
Henderson KN, Tye-Din JA, Reid HH et al. (2007). A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.. Immunity Vol.27, (1) 1074-7613 23-34.
10.1016/j.immuni.2007.05.015
Cartwright N, Murch O, McMaster SK et al. (2007). Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo. AM J RESP CRIT CARE Vol.175, (6) 1073-449X 595-603.
10.1164/rccm.200608-1103OC
van Bodegraven AA, Curley CR, Hunt KA et al. (2006). Genetic variation in myosin IXB is associated with ulcerative colitis.. Gastroenterology Vol.131, (6) 0016-5085 1768-1774.
10.1053/j.gastro.2006.09.011
Walters JR, Balesaria S, Chavele KM et al. (2006). Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women.. J Bone Miner Res Vol.21, (11) 0884-0431 1770-1777.
10.1359/jbmr.060721
McGovern DP, Butler H, Ahmad T et al. (2006). TUCAN (CARD8) genetic variants and inflammatory bowel disease.. Gastroenterology Vol.131, (4) 0016-5085 1190-1196.
10.1053/j.gastro.2006.08.008
van Heel DA, Playford RJ (2006). To the editor - Response. EUR J IMMUNOL Vol.36, (10) 0014-2980 2818-2819.
10.1002/eji.200636631
van Heel DA, Hunt KA, King K et al. (2006). Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease.. Inflamm Bowel Dis Vol.12, (7) 1078-0998 598-605.
10.1097/01.ibd.0000225344.21979.89
Hunt KA, Monsuur AJ, McArdle WL et al. (2006). Lack of association of MYO9B genetic variants with coeliac disease in a British cohort.. Gut Vol.55, (7) 0017-5749 969-972.
10.1136/gut.2005.086769
van Heel DA, West J (2006). Recent advances in coeliac disease.. Gut Vol.55, (7) 0017-5749 1037-1046.
10.1136/gut.2005.075119
van Heel DA, Hunt KA, Ghosh S et al. (2006). Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease.. Eur J Immunol Vol.36, (6) 0014-2980 1629-1635.
10.1002/eji.200535636
Anderson RP, van Heel DA, Tye-Din JA et al. (2006). Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease.. Gut Vol.55, (4) 0017-5749 485-491.
10.1136/gut.2005.064550
van Heel DA (2006). Interleukin 15: its role in intestinal inflammation.. Gut Vol.55, (4) 0017-5749 444-445.
10.1136/gut.2005.079335
Butler M, Ng CY, van Heel DA et al. (2006). Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium.. Eur J Immunol Vol.36, (4) 0014-2980 864-874.
10.1002/eji.200535497
van Heel DA, Ghosh S, Hunt KA et al. (2005). Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease.. Gut Vol.54, (11) 0017-5749 1553-1557.
10.1136/gut.2005.065888
van Heel DA, Dart J, Nichols S et al. (2005). Novel presentation of coeliac disease after following the Atkins' low carbohydrate diet.. Gut Vol.54, (9) 0017-5749 1342-.
10.1136/gut.2004.062588
Anderson RP, van Heel DA, Tye-Din JA et al. (2005). T cells in peripheral blood after gluten challenge in coeliac disease.. Gut Vol.54, (9) 0017-5749 1217-1223.
10.1136/gut.2004.059998
van Heel DA, Ghosh S, Butler M et al. (2005). Synergistic enhancement of Toll-like receptor responses by NOD1 activation.. Eur J Immunol Vol.35, (8) 0014-2980 2471-2476.
10.1002/eji.200526296
van Heel DA, Hunt K, Greco L et al. (2005). Genetics in coeliac disease.. Best Pract Res Clin Gastroenterol Vol.19, (3) 1521-6918 323-339.
10.1016/j.bpg.2005.01.001
van Heel DA, Ghosh S, Butler M et al. (2005). Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.. Lancet Vol.365, (9473) 1794-1796.
10.1016/S0140-6736(05)66582-8
McGovern DP, Hysi P, Ahmad T et al. (2005). Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease.. Hum Mol Genet Vol.14, (10) 0964-6906 1245-1250.
10.1093/hmg/ddi135
Hunt KA, McGovern DP, Kumar PJ et al. (2005). A common CTLA4 haplotype associated with coeliac disease.. Eur J Hum Genet Vol.13, (4) 1018-4813 440-444.
10.1038/sj.ejhg.5201357
Pierik M, Yang H, Barmada MM et al. (2005). The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction.. Inflamm Bowel Dis Vol.11, (1) 1078-0998 1-7.
Ghosh S, van Heel D, Playford RJ (2004). Probiotics in inflammatory bowel disease: is it all gut flora modulation?. Gut Vol.53, (5) 0017-5749 620-622.
Owens DW, Wilson NJ, Hill AJ et al. (2004). Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients.. J Cell Sci Vol.117, (Pt 10) 0021-9533 1989-1999.
10.1242/jcs.01043
van Heel DA, Fisher SA, Kirby A et al. (2004). Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs.. Hum Mol Genet Vol.13, (7) 0964-6906 763-770.
10.1093/hmg/ddh090
Frenz MB, van Heel D, Siuda G et al. (2004). Unusual malfunction of percutaneous endoscopic jejunostomy feeding tubes in patients with intestinal dysmotility.. Endoscopy Vol.36, (3) 0013-726X 234-235.
10.1055/s-2004-814253
McGovern DP, Van Heel DA, Negoro K et al. (2003). Further evidence of IBD5/CARD15 (NOD2) epistasis in the susceptibility to ulcerative colitis.. Am J Hum Genet Vol.73, (6) 0002-9297 1465-1466.
10.1086/379745
van Heel DA, Dechairo BM, Dawson G et al. (2003). The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants.. Hum Mol Genet Vol.12, (20) 0964-6906 2569-2575.
10.1093/hmg/ddg281
Walters JR, van Heel DA (2003). Detecting the risks of osteoporotic fractures in coeliac disease.. Gut Vol.52, (8) 0017-5749 1229-1230.
Armuzzi A, Ahmad T, Ling KL et al. (2003). Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31.. Gut Vol.52, (8) 0017-5749 1133-1139.
O'Callaghan NJ, Adams KE, van Heel DA et al. (2003). Association of TNF-alpha-857C with inflammatory bowel disease in the Australian population.. Scand J Gastroenterol Vol.38, (5) 0036-5521 533-534.
Negoro K, McGovern DP, Kinouchi Y et al. (2003). Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease.. Gut Vol.52, (4) 0017-5749 541-546.
van Heel DA, McGovern DP, Cardon LR et al. (2002). Fine mapping of the IBD1 locus did not identify Crohn disease-associated NOD2 variants: implications for complex disease genetics.. Am J Med Genet Vol.111, (3) 0148-7299 253-259.
10.1002/ajmg.10588
Ahmad T, Marshall SE, Mulcahy-Hawes K et al. (2002). High resolution MIC genotyping: design and application to the investigation of inflammatory bowel disease susceptibility.. Tissue Antigens Vol.60, (2) 0001-2815 164-179.
Crane AM, Bradbury L, van Heel DA et al. (2002). Role of NOD2 variants in spondylarthritis.. Arthritis Rheum Vol.46, (6) 0004-3591 1629-1633.
10.1002/art.10329
van Heel DA, Udalova IA, De Silva AP et al. (2002). Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.. Hum Mol Genet Vol.11, (11) 0964-6906 1281-1289.
van Heel DA, Carey AH, Jewell DP (2001). Identification of novel polymorphisms in the beta7 integrin gene: family-based association studies in inflammatory bowel disease.. Genes Immun Vol.2, (8) 1466-4879 455-460.
10.1038/sj.gene.6363810
McGovern DP, van Heel DA, Ahmad T et al. (2001). NOD2 (CARD15), the first susceptibility gene for Crohn's disease.. Gut Vol.49, (6) 0017-5749 752-754.
Dechairo B, Dimon C, van Heel D et al. (2001). Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3).. Eur J Hum Genet Vol.9, (8) 1018-4813 627-633.
10.1038/sj.ejhg.5200687
Van Heel DA, McGovern DP, Jewell DP (2001). Crohn's disease: genetic susceptibility, bacteria, and innate immunity.. Lancet Vol.357, (9272) 0140-6736 1902-1904.
10.1016/S0140-6736(00)05091-1
Cavanaugh J, IBD International Genetics Consortium (2001). International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16.. Am J Hum Genet Vol.68, (5) 0002-9297 1165-1171.
10.1086/320119

Teaching

PhD students

Vanisha Mistry

2nd student co-supervised with Professor David Kelsell

Previous:

  • Dr Patrick Dubois
  • Dr Graham Heap
  • Dr Karen Hunt

Contact

Centre for Digestive Diseases
Blizard Institute
Barts and The London School of Medicine and Dentistry
Blizard Building
4 Newark Street
London
E1 2AT 
020 7882 2330
This email address is being protected from spambots. You need JavaScript enabled to view it.