Martineau, Adrian

Adrian R Martineau

Title: Dr
B Med Sci DTM&H MRCP PhD
Clinical Reader in Respiratory Infection and Immunity

Adrian’s primary research interest is in the immunomodulatory actions of vitamin D in respiratory infection. This translational programme of work combines in vitro investigation with a series of multi-centre clinical trials, investigating potential utility of vitamin D supplementation as an adjunct in the treatment of tuberculosis, and in the prevention of acute respiratory infections and exacerbations of asthma and chronic obstructive pulmonary disease. Other interests include the role of neutrophils in the immune response to tuberculosis, and the effects of vitamin D supplementation in a range of non-communicable diseases: he is clinical Chief Investigator for the Vitamin D and Longevity (VIDAL) trial, a national study investigating effects of vitamin D supplementation on all-cause mortality in adults aged 65-84 years.

Adrian has an active PhD programme and enquiries from prospective PhD or MD students interested in respiratory infection and / or vitamin D are welcome.

Research group

PhD students:
Dr David Lowe
Claire Kelland
David Jolliffe

Trial co-ordinators:
Zuhur Balayah
Wai Yee James
Beverley MacLaughlin

Research Assistants:
Kamrul Islam
Kate Kilpin
Mital Patel
Dr Karolina Witt

Bio

 

Adrian gained a B Med Sci degree in Epidemiology and Public Health from Newcastle University in 1995, and graduated from Newcastle Medical School in the following year. He then gained a Diploma in Tropical Medicine and Hygiene from Liverpool University before working as a Medical Officer in South Africa. He returned to Liverpool to continue medical training in 1999, and became a member of the Royal College of Physicians in 2001. Adrian joined Queen Mary as a lecturer in Respiratory Medicine in 2002, and established a programme of laboratory and clinical research into the immunomodulatory actions of vitamin D in tuberculosis. He received his PhD in 2010, and is currently conducting clinical trials of vitamin D supplementation to prevent exacerbations of asthma and COPD and all-cause mortality.

 

Research

Vitamin D
Tuberculosis
Acute respiratory infection
Asthma
COPD

Vindaloo trial

VIDAL trial
 

Publications

Key Publications

Coussens AK, Wilkinson RJ, Hanifa Y, Nikolayevskyy V, Elkington PT, Islam K, Timms PM, Venton TR, Bothamley GH, Packe GE, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Mein CA, Bhaw-Rosun L, Nuamah R, Young DB, Drobniewski FA, Griffiths CJ, Martineau AR. Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment. Proc Nat Acad Sci USA 2012 Sep 18;109(38):15449-54.

Martineau AR. Bolus-dose vitamin D to prevent infant pneumonia. Lancet 2012 Apr 14;379(9824):1373-5.

Lowe DM, Redford PS, Wilkinson RJ, O’Garra A, Martineau AR. Neutrophils and tuberculosis: a double-edged sword? Trends Immunol 2012;33(1):14-25

Martineau AR, Nhamoyebonde S, Oni T, Rangaka MX, Marais S, Bangani N, Tsekela R, Bashe L, de Azevedo V, Caldwell J, Venton TR, Timms PM, Wilkinson KA, Wilkinson RJ. Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa. Proc Nat Acad Sci USA 2011;108(47):19013-7

Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, Packe GE, Moore-Gillon JC, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Woodward NJ, Venton TR, Barnes KE, Mullett CJ, Coussens AK, Rutterford CM, Mein CA, Davies GR, Wilkinson RJ, Nikolayevskyy V, Drobniewski FA, Eldridge SM, Griffiths CJ. High-dose vitamin D3 during intensive phase treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 2011;15:377:242-50

Martineau AR, Newton, SM, Wilkinson KA, Kampmann B, Hall BR, Nawroly N, Packe GE, Davidson RN, Griffiths CJ, Wilkinson RJ. Neutrophil-mediated innate immune resistance to mycobacteria. J Clin Invest 2007;117:1988-94

Martineau AR, Wilkinson KA, Newton SM, Norman AW, Packe GE, Skolimowska K, Davidson RN, Kampmann B, Griffiths CJ, Wilkinson RJ. Interferon gamma- and tumour necrosis factor-independent vitamin D-inducible human suppression of mycobacteria by cathelicidin LL-37. J Immunol 2007;178:7190–7198

Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ. A single dose of vitamin D enhances immunity to mycobacteria. Am. J Respir. Crit Care Med 2007;176:208-13


All publications from PubLists

 

Teaching

Ad hoc postgraduate teaching

Undergraduate teaching (PBL and OSCEs)

Topics for PhD supervision:
Respiratory infection
Vitamin D

PhD Students:

Dr David Lowe
Claire Kelland
David Jolliffe

Further information

ARREST trial
I chair the steering committee for the ARREST trial (Multicentre trial of adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia).

Vitamin D Podcast, Wellcome Collection
http://www.wellcomecollection.org/whats-on/events/packed-lunch-podcast/vitamin-d.aspx

BBC Radio 4 'Case Notes' on vitamin D

BBC Radio 4 'Inside Health' on vitamin D and TB

New York Times on vitamin D and TB

'Vitamin D on Trial' in Science

Contact

Room 2.05, Yvonne Carter Building
Barts and The London School of Medicine and Dentistry
Yvonne Carter Building
58 Turner Street
Whitechapel
London E1 2AB

+44 20 7882 2551
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